Lung Cancer

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Rush Limbaugh's widow, Kathryn Adams Limbaugh, has sold her husband's longtime Florida compound of 20-plus years for a whopping $155 million. This marks a record for the Palm Beach area, which has seen a slew of big-time deals in the past few years, according to the Wall Street Journal. In 2013, hedge funder Ken Griffin paid $129.6 million for four parcels in the area, making that the most recent record — until now. Comprising 2.7 acres, the waterfront property was quietly shopped off the market for the past eight months. The new buyer purchased the property, which is made up of three homes — 1495 North Ocean Boulevard, 1501 North Ocean Boulevard, and 108 Mediterranean Road — under an anonymous LLC. Rush Limbaugh and Kathryn Adams Limbaugh expanded the home to include three additional structures. ZUMAPRESS.com Limbaugh bought the homes back in 1998 for $3.9 million when he was married to his th...

If you notice a toenail becoming discolored and turning black, it's often due to injury that causes a bruise called a subungual hematoma . There can be other reasons for discoloration, however, and black toenail can be painful. This article will discuss black toenail, including what can cause it, what to do about it, and if you should call your healthcare provider. Photographer, Basak Gurbuz Derman / Getty Images Symptoms of Black Toenail The most common symptom of black toenail is exactly that—the nail appears black, which is usually due to blood collecting underneath the nail. However, the discoloration can also be reddish, purplish, or brownish. Other symptoms include: Pain Nail separates from nail bed over time Thickening and splitting of the nail If the area becomes infected, you may note: Swelling Odor Redness Discharge Some nail discoloration appears as striations, or lines, in the nail that are usually ver...

By Clinical Content Hub Raja Mudad, MD Sylvester Comprehensive Cancer Center, University of Miami, Florida Key Takeaways In patients with metastatic rearranged during transfection (RET) fusion-positive non-small cell lung cancer (NSCLC), treatment with selective RET inhibitors is associated with improved response and greater tolerability compared with traditional treatment strategies. While patients treated with RET-selective inhibitors do not experience the hair loss, reduced blood count, or immune suppression associated with traditional cancer therapies, they may experience side effects such as skin rash, increased blood pressure, liver damage, and slow wound healing. Recommended measures to help manage these risks include liver function testing every 2 weeks during the first 3 months of therapy and optimization of blood pressure in hypertensive patients prior to treatment initiation. The development of acquired resistance remains a significant challenge with s...

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KEYTRUDA® (pembrolizumab) Plus Chemotherapy Significantly Improved Progression-Free Survival Compared to Chemotherapy Alone as First-Line Therapy for Advanced or Recurrent Endometrial Carcinoma, Regardless of Mismatch Repair Status March 27, 2023 5:15 pm ET KEYTRUDA plus chemotherapy reduced risk of disease progression or death by 46% in patients whose cancer was mismatch repair proficient (pMMR) and by 70% in patients whose cancer was mismatch repair deficient (dMMR), compared to chemotherapy alone Results from Phase 3 NRG-GY018 trial to be presented at Society of Gynecologic ...