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Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies distinct proteotypes associated with patient outcomes

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leukemia patient :: Article Creator Self-Care Education Reduces Nausea After SCT For Leukemia Photo Credit: Klebercordeiro A mobile app offering treatment and self-care information reduced nausea and vomiting in patients who underwent stem cell transplantation for leukemia. Self-care education via a smartphone app significantly improved the severity of nausea and vomiting up to three months after stem cell transplantation (SCT) in patients with leukemia, according to study results published in Hematology, Transfusion and Cell Therapy. "Therefore, this method is recommended to reduce the severity of nausea and vomiting in patients with leukemia who undergo transplantation," wrote corresponding author Zakerimoghadam Masoumeh, PhD, and study coauthors. The research team developed the app used in the study. The app included information on leukemia and treatments, adverse effects, and self-care for patients. Post-transplant nutritio

MicroRNAs: circulating biomarkers for the early detection of imperceptible cancers via biosensor and machine-learning advances

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types of carcinoma :: Article Creator New Drug Approved For Common Type Of Breast Cancer Recurrence Oct. 14, 2024 – A new breast cancer drug has received quick federal approval after a clinical trial showed it could more than double the time before a common type of breast cancer recurrence worsens. The FDA approved Itovebi for people with hormone-sensitive breast cancer that returned while or after taking endocrine therapy, such as the medicine tamoxifen. Itovebi is only approved for people who have a genetic mutation called PIK3CA and whose cancer type is HER2-negative. (HER2 refers to a protein that can affect cancer growth.) Along with its approval of the new drug, the FDA approved a genetic test called FoundationOne Liquid CDx as an option to identify people with the PIK3CA mutation. The mutation occurs in 40% of breast cancers that are hormone-sensitive and HER2-negative. One of the researchers from the clinical trial for Itovebi called t

A highly expressed mRNA signature for predicting survival in patients with stage I/II non-small-cell lung cancer after operation

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tnm small cell lung cancer :: Article Creator Mutation-Driven Metastatic Patterns In Non-Small Cell Lung Cancer Photo Credit: Mohammed Haneefa Nizamudeen The following is a summary of "Association of mutation profiles with metastasis in patients with non-small cell lung cancer," published in the October 2024 issue of Oncology by Li et al.       Patients of non-small cell lung cancer (NSCLC) often experience varied metastatic patterns, which may be influenced by specific gene mutations.   Researchers conducted a retrospective study to analyze the correlation between common gene mutation types and metastatic sites in patients with NSCLC.   They enrolled1,586 patients with NSCLC and used fluorescence polymerase chain reaction (PCR) to detect mutations in EGFR, ALK, ROS1, RET, MET, BRAF, HER2, KRAS, NRAS, and PIK3CA genes while also examining factors such as sex, smoking status, age at diagnosis, histological type, and TNM stage. T

Notch signaling pathway: architecture, disease, and therapeutics

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copd x diagnosis :: Article Creator When To Worry About Lung Nodules Plus How To Prevent Them Picture this: Your doctor orders an imaging test like a chest X-ray in preparation for an upcoming procedure, and the results show a small white spot in the center of your lungs—a pulmonary or lung nodule. Suddenly, you're wondering what this means for your health. Should you be concerned? Here, doctors explain when to worry about lung nodules, symptoms to look for plus how to prevent them in the first place. What are lung nodules? "A lung nodule is a small, solid, rounded mass of tissue in the lungs that can be seen on a chest computed tomography (CT) scan or X-ray as a white spot," explains Samir Shah, MD, an interventional radiologist and Chief Medical Officer at Qure.Ai.  Pulmonary nodules typically form when a bacterial or viral infection irritates the lung tissue. This causes a small clump of cells called a granuloma to form. The no

Bloom Syndrome Complicated by Low-Grade Lymphoma and Non-small Cell Lung Cancer: A Case Report

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lung cancer that starts with an a :: Article Creator For People With Lung Cancer, Exercise Can Be Gruelling. It's Also Among The Most Important Things When you think of lung cancer treatment, what comes to mind – chemotherapy, radiation, surgery? While these can be crucial, there's another powerful tool that's often overlooked: exercise. Our recent study, published in the Journal of Science and Medicine in Sport, challenges the common belief that people with lung cancer are too sick to be physically active. In fact, we found exercise can play a vital role in improving life for those battling this disease. What we did and what we found Our review involved analysing 26 high quality studies on how best to incorporate exercise into treatment for lung cancer. We found the overwhelming weight of evidence shows exercise offers benefits at every stage of the lung cancer journey. This includes: before surgery (being more fit can lead

25 year trends in cancer incidence and mortality among adults aged 35-69 years in the UK, 1993-2018: retrospective secondary analysis

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new treatments for bile duct cancer :: Article Creator Chemotherapy For Bile Duct Cancer (Cholangiocarcinoma) Chemotherapy is a drug or a combination of drugs that kills cancer cells wherever they are in the body. You may receive chemotherapy before surgery to shrink a bile duct tumor. This is called neoadjuvant therapy. If you receive chemotherapy after surgery to destroy and cancer cells that may remain, it is called adjuvant therapy. The standard chemotherapy drugs for bile duct cancer are gemcitabine (Gemzar®) and cisplatin. Other drugs sometimes used include fluorouracil (also called 5-FU), oxaliplatin (Eloxatin®), and capecitabine (Xeloda®). We will carefully tailor your treatment to make sure that it's as effective as possible while helping maintain your quality of life. If you have bile duct cancer that has spread, you may receive chemotherapy as the main treatment if surgery is not an option. Research has suggested that the combinat

Influence of Estrogen on the NSCLC Microenvironment: A Comprehensive Picture and Clinical Implications

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symptoms of uterine cancer after menopause :: Article Creator Uterine Cancer Rates Are Increasing: What Can You Do To Protect Yourself? Uterine cancer is the most common type of gynecologic cancer. It's estimated that about 67,880 new cases will be diagnosed in 2024. Approximately 13,250 people will die from this disease in the U.S. In 2024, according to the National Cancer Institute. Researchers recently reported that while death rates for the most common type of uterine cancer—endometrioid cancer—remained stable, deaths from rare and aggressive types of uterine cancer increased significantly each year from 2010 to 2017. The study also revealed a disproportionate increase in uterine cancer deaths among the Hispanic, Black and Asian communities. Although uterine cancer can't be fully prevented, and there is no standard screening for it, an annual pelvic examination is recommended. Kristina Butler, M.D., a Mayo Clinic gynecologic on