Clinical Trial Treatment for Lung Cancer

Guang-Shing Cheng, MD

Clinical Expertise

Dr. Cheng is a pulmonologist and critical care specialist who sees patients at the Fred Hutch with respiratory problems including complications of their cancer treatment. She also has expertise in diagnosing lung nodules due to a variety of causes, including lung cancer. She attends in the Pulmonary Consult Service and the Lung Cancer Early Detection and Prevention Clinic at Fred Hutch. Dr. Cheng performs bronchoscopies for the diagnosis of respiratory infections and lung cancer. She also attends in the Intensive Care Unit at the University of Washington.

She has authored multiple manuscripts in peer-reviewed journals about BOS and other lung complications after HCT. She edited an issue of Clinics in Chest Medicine on pulmonary disease in non-pulmonary malignancies. In addition, she has authored two chapters in Murray and Nadel, a definitive test on pulmonary disorders.

Current Projects

Dr. Cheng's goal is to improve outcomes for stem cell transplant patients with infectious and non-infectious lung disease. Her research focuses on bronchiolitis obliterans syndrome (BOS), which is a complication of chronic graft-versus-host disease in patients who have received HCT. Currently, there are no therapies that routinely reverse the course of the disease. Dr. Cheng is working to develop early detection and prevention strategies for HCT patients, including the use of wireless handheld spirometry monitoring, which may lead to earlier treatment. She is also involved in multicenter trials testing new drugs for the treatment of BOS and other lung diseases after HCT. She is investigating the relationship between respiratory viral infection and the development of lung disease in these patients.

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