Lung Metastases Imaging: Practice Essentials, Radiography, Computed Tomography

Stomach Cancer

Treatment options for stomach cancer depend on the cancer's type, stage, and location.

Surgery There are various types of surgical procedures available for treating stomach cancer, including:

[15]

Endoscopic resection: A procedure that can be used for very early stage cancers to remove the tumor and parts of the normal stomach wall below and around it

Gastrectomy: An invasive procedure to remove part or all of the stomach, and possibly nearby lymph nodes, other parts of the gastrointestinal tract, other tissues near the tumor, and the spleen

In some cases, a tumor may grow within the passage into or out of the stomach, affecting the ability to eat normally. Surgeons may insert a thin, expandable tube called an endoluminal stent from the esophagus to the stomach or from the stomach to the small intestine. In other cases, they may use endoluminal laser therapy to cut through and open a blockage.

[16]

Chemotherapy Chemotherapy uses drugs to kill cancer cells, often used before or after surgery. It may also be the main treatment course if the cancer has spread (metastasized) to other parts of the body, or if surgery is not an option for some reason.

[17]

Many different chemotherapy drugs may be used alone or in combination with one another. The drugs used will differ depending on the stage of stomach cancer. Some of the chemotherapy drugs used for stomach cancer include:

Capecitabine

Carboplatin

Cisplatin

Docetaxel

Epirubicin

Irinotecan

Oxaliplatin

Paclitaxel

Chemotherapy may be delivered into the vein using a needle or catheter, or into the abdominal cavity through a port. These drugs may cause a range of side effects, including nausea and vomiting, hair loss, mouth sores, and fatigue.

Targeted Drug Therapy During targeted drug therapy, drugs or other substances target specific changes in cells that cause cancer. It works differently than chemotherapy and is sometimes effective when chemotherapy is not. It may also be used in conjunction with chemo.

[18]

For example, the drug trastuzumab (Herceptin) targets the HER2 protein that is sometimes over-produced in people with stomach cancer. Trastuzumab blocks HER2-positive cells from sending chemical signals that tell them to grow, while also stimulating the immune system to kill cells with lots of HER2. Side effects of trastuzumab tend to be mild, and include fever, chills, nausea, and headache. Other targeted drugs may have more serious side effects.

[19]

Targeted drugs used for stomach cancer include:

[18]

trastuzumab (Herceptin)

fam-trastuzumab deruxtecan (Enhertu)

ramucirumab (Cyramza)

larotrectinib (Vitrakvi)

entrectinib (Rozlytrek)

zolbetuximab (Vyloy)

Immunotherapy

Sometimes considered a form of targeted therapy, immunotherapy works by helping the immune system better find and destroy cancer cells. Drugs like nivolumab (Opdivo) and pembrolizumab (Keytruda) target a protein called PD-1 that keeps the immune system's T-cells from attacking other cells in the body. The drugs block PD-1, allowing T-cells to attack cancer cells.

Common side effects include fatigue, itching and rash, loss of appetite, muscle pain, and joint pain, among others.

[20]

Radiation Therapy Radiation therapy uses high-energy rays to target and destroy cancer cells. Like chemotherapy, radiation therapy may be used before or after surgery. Sometimes it's used along with chemotherapy.

[21]

Radiation therapy is administered using a machine outside the body. Computers are used to aim the radiation directly at the cancer from multiple angles, limiting the damage to nearby tissues. You may experience some skin problems like redness and peeling, gastrointestinal issues like vomiting and diarrhea, and fatigue from radiation therapy.

[21]

Stomach Cancer Can Be Caused By A Bacterium Carried By Half The People On Earth, But Screening For It Isn't Easy

Just a moment...

This request seems a bit unusual, so we need to confirm that you're human. Please press and hold the button until it turns completely green. Thank you for your cooperation!

Press and Hold

Press and hold the button

If you believe this is an error, please contact our support team.

167.71.87.121 : bc187a9a-42a4-455e-b4a0-fa081bc9

PAX-1 By Komipharm International For Gastric Cancer: Likelihood Of Approval

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

PAX-1 overview

PAX-1 is under development for the treatment of cancer pain, inflammatory pain, neuropathic pain, newly diagnosed glioblastoma and recurrent glioblastoma and non-small cell lung carcinoma, lymph non-small cell lung carcinoma, metastatic breast cancer, metastatic soft-tissue cancer, metastatic osteosarcoma, metastatic gastric cancer, metastatic renal cancer, metastatic ovarian cancer, metastatic bladder cancer, metastatic cervical cancer, metastatic endometrial cancer, metastatic head and neck cancer, metastatic prostate cancer, malignant melanoma, cholangiocarcinoma, prostate cancer and multiple myeloma, brain cancer. It is a non narcotic cancer pain reliever. The drug candidate is arsenic oxide. It administered through oral route as a tablet. It acts by targeting IL-18 and IL-1B.

It was under development for coronavirus disease 2019 (covid-19) pneumonia.

Komipharm International overview

Komipharm International (Komipharm) offers pharmaceutical and animal health products. The company's product pipeline includes PAX-1-001, a non-opioid drug candidate designed to treat cancer pain; PAX-1-002 for treating brain cancer; PAX-1-004 against gallbladder, prostate cancer and multiple myeloma; KML001 an oral drug used for the treatment of prostate, solid, biliary tract, lung and liver cancer and malignant lymphoma; PAX-1-003, to treat lung to brain metastases, head and neck cancer, metastatic melanoma, osteosarcoma and soft tissue cancer. It also develops vaccines and medical products for treating fever, pain, skin problems and other diseases in animals. Komipharm works in partnership with other pharmaceutical companies worldwide to develop its pipeline products. The company operates production facilities in Australia, the US and South Korea. Komipharm is headquartered in Siheung, South Korea.

For a complete picture of PAX-1's drug-specific PTSR and LoA scores, buy the report here.

From

The gold standard of business intelligence.

Blending expert knowledge with cutting-edge technology, GlobalData's unrivalled proprietary data will enable you to decode what's happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors.

Be better informed

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData's Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData's Pharmaceutical Intelligence Center.

---