Lung Cancer

Study findings presented during the 2021 AUA annual meeting showed that large surface area microparticle docetaxel (LSAM-DTX; NanoDoce) is safe with early signs of clinical activity in patients with high-risk non–muscle invasive bladder cancer (NMIBC). 1 Among the 19 patients who received LSAM-DTX at any dose level in the phase 1/2 trial (NCT03636256), the 3-month complete response (CR) rate was 68%. The 6-month durability in 13 evaluable patients who had a CR at 3 months was 62% and the 12-month durability in this group was 31%. "LSAM-DTXs are large surface area microparticles of pure drug in powder form," explained Max Kates, MD, the director of the Bladder Cancer Program and an assistant professor of urology at the Johns Hopkins University School of Medicine in Baltimore, Maryland. "The microparticles are formed using supercritical precipitation technology, then suspended in saline prior to use. The uniqueness of this technology relative to other particle engineering ...

Excessive smoking can lead to smoker's leg. In this circulatory disease, blood vessels narrow and restrict blood flow to the lower limbs. In people with smoker's leg, blood flow reduction may cause leg pain or cramps when walking. The treatment options for smoker's leg may include lifestyle changes, prescription medications, and, in severe cases, surgery. In this article, we discuss the causes of smoker's leg. We also look at how to treat and prevent the condition. Smoker's leg refers to symptoms in the leg resulting from a condition that doctors call peripheral artery disease (PAD). PAD causes narrowing of the blood vessels, which reduces blood flow to the arteries in the leg. It can also affect blood flow to the: arms stomach brain According to the Centers for Disease Control and Prevention (CDC), more than 6.5 million people in the United States aged 40 years and above have PAD. PAD is more common in African Americans than in people belonging to other racial gr...

It's not a generalization to say that men aren't particularly great about sun protection. "I ask every person that I perform a skin examination on whether or not they wear sunscreen daily. Easily 70 percent of male patients say that they do not," board-certified dermatologist Corey L. Hartman , founder of Skin Wellness Dermatology , tells BAZAAR.com . "According to reports, only about 14 percent of men use sunscreen on their faces and other sun-exposed skin when going outside." Skin experts unanimously agree that even the most minimalist of skin care routines calls for broad-spectrum UV protection of at least SPF 30 every single day. It's recommended for cosmetic concerns like preventing dark spots, melasma, and photoaging, but more importantly, for the prevention of skin cancer—the fourth most common cause of death for adults between the ages of 24 and 29, according to board-certified dermatologist Eva Simmons-O'Brien, cofounder of Simmons-O'Bri...

Upper back pain when breathing has a wide range of possible causes. These include infections, injuries, and heart problems. If the cause is not obvious, a person may wish to seek medical advice. Pain when breathing can be a symptom of a serious health condition. Pain in the upper back when breathing usually extends around the chest. A sharp pain could be a sign of pleurisy or a heart attack. A dull ache might be due to a fractured vertebra or muscle strain. Looking out for other symptoms can sometimes help a person identify the cause of the pain. If upper back pain is causing ongoing difficulty breathing, it is important to seek medical advice, as there may be a serious cause. Pain can make a person avoid taking deep breaths. Shallow breathing can result in insufficient oxygen getting into the body, which may damage health over time. Keep reading to learn more about some of the possible causes of upper back pain when breathing. Share on Pinterest The possible causes of upper back pain ...

Long-term survival was equivalent for patients with early-stage non-small-cell lung cancer (NSCLC) whether treated with stereotactic ablative radiotherapy (SABR) or surgery, according to updated results from a prospective study. In an analysis of an additional 80 patients with medically operable, stage IA NSCLC treated with SABR, the overall survival (OS) rate was 91% at 3 years and 87% at 5 years, reported Joe Chang, MD, of MD Anderson Cancer Center in Houston, and colleagues in The Lancet Oncology . In comparison, OS following video-assisted thoracoscopic surgical lobectomy with mediastinal lymph node dissection (VATS L-MLND) in a similar cohort of early-stage NSCLC patients was again 91% at 3 years and 84% at 5 years. Progression-free survival (PFS) rates at 3 years were also similar between the two groups, at 80% for the SABR-treated patients and 88% for the surgically treated patients. At 5 years, these rates were 77% and 80%, respectively. "Long-term results of this ...

Lung cancer often doesn't cause symptoms in its early stages. But as the cancer grows, you may develop warning signs, such as a persistent cough or shortness of breath. Any symptoms you experience may vary based on factors such as tumor location and the specific type of lung cancer you have. Keep reading to learn about the more and less common symptoms of lung cancer, as well as risk factors for the disease. Lung cancer can cause symptoms that affect your lungs and general symptoms similar to those of many other types of cancer. The most common symptoms of lung cancer include: Some of the rarer symptoms of lung cancer are associated with certain types of lung cancer. Depending on the location of the cancer or how your immune system responds to it, these types of cancer may cause their own unique set of symptoms. Horner syndrome Cancers located in the upper part of the lungs are called Pancoast tumors. These tumors can affect the nerves of the eyes and face. Symptoms associated with...

Small-Cell Lung Cancer Small-cell lung cancer (SCLC) is the most aggressive type of lung cancer, characterized by a rapid doubling time. 1 This form of lung cancer is most frequently diagnosed in patients who have a history of heavy smoking. 2 SCLC accounts for about 13% to 15% of all new lung cancer diagnoses, with over 200,000 new cases occurring each year worldwide. 1,2 With its rapid growth, SCLC tends to metastasize early in the disease course. 1,2 Based on the Veterans Administration Lung Study Group classification scheme, when SCLC is confined to one hemithorax that can be safely encompassed within a tolerable radiation field, the disease is described as limited-stage SCLC. 2,3 Limited-stage SCLC may present with regional lymph node involvement. 2 Treatment of limited-stage SCLC typically consists of chemotherapy, often combined with radiation therapy. 3 Based on recommendations by the National Comprehensive Cancer Network (NCCN) guidelines, preferred regimens in this setting...