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The Current Treatment Paradigm for Pancreatic Ductal Adenocarcinoma and Barriers to Therapeutic Efficacy

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dr shahrour pulmonologist :: Article Creator

Evaluation of the association of chronic inflammation and cancer: Insights and implications

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lungs :: Article Creator Researchers Explore How Mechanical Signals Influence Viral Infections In Lungs Researchers at Rochester Institute of Technology are investigating how mechanical forces—such as stretching and changes in tissue stiffness—influence viral infection rates in the lungs to understand how disease progression can be reduced. The process combines virology and mechanobiology, two distinct areas of study that had not been explored at the same time but might prove to be a way to better understand disease progressions to intervene earlier and improve patient outcomes. RIT professors Karin Wuertz-Kozak, a bioengineer, and Maureen Ferran, a virologist, are investigating the relationship between mechanical forces, such as changes in stiffness or stretching, and viral pathogenesis in lung tissue through a National Science Foundation grant they recently received. Understanding how cells respond to mechanical signals could help in underst...

Figure 3: 56-year-old woman with breast cancer (breast cancer cell...

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sclc staging :: Article Creator Updated TNM Staging System For SCLC Offers Better Predictive Power Photo Credit: Mohammed Haneefa Nizamudeen Researchers recently validated the ninth edition of the TNM staging system for SCLC, finding improved accuracy and predictive power. The tumor-node-metastasis (TNM) staging system plays a critical role in the prognostic assessment and treatment decisions for lung cancer. Guidelines recommend treatment modalities for patients with small-cell lung cancer (SCLC), which accounts for approximately 10% of the global incidence of lung cancer, based on the TNM classification. The ninth edition of the TNM staging system (TNM-9) of lung cancer was presented at the 2023 World Conference on Lung Cancer, but there remained a need for proper external validation of the staging system. Previously, researchers validated the TNM-9 using data from the Surveillance, Epidemiology, and End Results (SEER) database from patients...

Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets

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esophageal small cell carcinoma :: Article Creator Esophageal Squamous Cell Carcinoma Survival Trends Show Demographic Disparities The risk of mortality due to squamous cell carcinoma (SCC) of the upper esophagus is higher in men vs women and among non-Hispanic Black patients compared with other racial groups, according to results of a retrospective study published in Diseases of the Esophagus. Esophageal malignancies, of which SCC and adenocarcinoma are predominant subtypes, comprise 3% of cancers globally and are characterized by significant health challenges and poor survival rates. To assess demographic factors associated with survival trends in patients with SCCE, researchers analyzed data from the National Cancer Institute's surveillance, epidemiology, and end results database. Eligible study patients were those aged 45 years and older who were diagnosed with SCC of the upper one-third of the esophagus between 2000 and 2020. They wer...

Mechanism insights and therapeutic intervention of tumor metastasis: latest developments and perspectives

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lung cancer stages life expectancy :: Article Creator Why Is There An Increase In Lung Cancer Among Women Who Have Never Smoked? Lung cancer cases are increasing in people who have never smoked, especially in women, a new study by the World Health Organization's cancer agency has found. The findings, published in The Lancet Respiratory Medicine, reveal that lung adenocarcinoma, the most common type of lung cancer among non-smokers, accounts for nearly 60% of lung cancer cases in women compared to 45% in men. About 2.5 million new lung cancer cases were diagnosed worldwide in 2022 – an increase of 300,000 since 2020. The study suggests that environmental factors, particularly air pollution, along with genetic predisposition and immune responses, may be driving this rise in non-smoking-related lung cancer. One of the most significant risk factors for lung cancer in non-smokers is genetic mutations, especially mutations in the EGFR gene. This...

Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets

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lung cancer type in smokers :: Article Creator Lung Cancer Without Smoking? Lung cancer is not just a smoker's disease anymore. Air pollution is emerging as a major risk factor, especially in cities. Protect your lungs, and breathe clean! Highlights: Pollution in the air, especially in cities and industrial areas, is filled with tiny particles that can enter the lungs Smoking is a major cause, lung cancer can also occur in people who have never smoked Wear a mask in highly polluted areas, especially if you have existing respiratory problems Lung cancer has long been thought to be caused primarily by smoking, but in recent years, more and more cases are being found in people who have never smoked (1✔ ✔Trusted SourceEstimated worldwide variation and trends in incidence of lung cancer by histological subtype in 2022 and over time: a population-based studyGo to source). This increases the concerns about other possible causes, with a...

Evaluation of the association of chronic inflammation and cancer: Insights and implications

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dr mohan kumar pulmonologist :: Article Creator Dr. Mohan Kumar, General Medicine Doctor / Internal Medicine Doctor Dr. Mohan Kumar is a General Medicine Doctor / Internal Medicine Doctor practicing in Kozhikode, specializing in the field of General Medicine / Internal Medicine. Are you the doctor associated with this profile? If yes, we invite you to register and claim your profile for free. Verification of your profile is essential for maintaining your digital presence, in compliance with the Telemedicine Guidelines issued by the National Medical Commission in the year 2020 (1). Additionally, the National Health Authority mandates verification and registration for doctors practicing teleconsultation(2) Purpose of Displayed Information:This information is intended to help your patients find you easily and book appointments. It is publicly accessible and does not infringe on your privacy. Need Updates or Have Concerns? Advertisement ...