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What To Know About Your Non-Small Cell Lung Cancer Prognosis

Doctors treat non-small cell lung cancer (NSCLC) with surgery, chemotherapy, and other medical treatments. Typically, an earlier diagnosis leads to a better outlook.

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. NSCLC grows and spreads less aggressively than small-cell lung cancer.

This means that doctors can treat it successfully with surgery, chemotherapy, and other medical treatments. Your prognosis will vary, but the earlier a diagnosis is made, the better the outlook.

Smoking is the leading cause of NSCLC and other types of lung cancer. Other risk factors include:

  • exposure to asbestos
  • air and water pollutants
  • secondhand smoke
  • The prognosis for NSCLC depends on several factors.

    The most important factor is the stage of the disease. The 5-year survival rate is the percentage of people with that stage of cancer that are alive 5 years after diagnosis.

    The current survival rates for NSCLC are based on the data of people who received an NSCLC diagnosis between 2012 and 2018. According to the American Cancer Society, the 5-year survival rates for NSCLC are:

  • Localized: 65%
  • Regional: 37%
  • Distant: 9%
  • Other factors can also affect your individual outlook. These can include:

  • your subtype of NSCLC
  • specific genetic mutations in the tumor
  • how well the tumor responds to treatment
  • your age and overall health
  • When you receive a diagnosis of NSCLC, it's natural to feel overwhelmed. It's important to work with your team of doctors and specialists to come up with a treatment plan for your particular situation.

    You may work with a primary doctor, surgeon, oncologist, radiologist, and other specialists. Together, they'll develop a treatment plan, answer your questions, and address your concerns.

    If you're diagnosed with NSCLC, your doctor will stage your cancer. Staging shows how far the cancer has spread and informs your treatment plan.

    For accurate staging, a doctor orders a variety of pre-staging diagnostic tests. These tests may include:

  • biopsies
  • ultrasounds
  • MRIs
  • bronchoscopies
  • surgery
  • CT scans
  • PET scans
  • The stages of lung cancer include localized, regional, and distant. These stages are defined as:

  • Localized: cancer is only in the lungs
  • Regional: cancer has spread outside the lungs to nearby structures, like the lymph nodes
  • Distant: cancer has spread to distant organs like the liver or brain
  • The earlier the stage at the time of diagnosis, the more likely the cancer will be treatable.

    When lung cancer is diagnosed at later stages, the possibility of a cure may be low. Instead, the goal of treatment may focus on managing the growth of the cancer and preventing it from spreading to other areas outside the lung.

    Early stage treatments

    Treatment for NSCLC varies depending on the stage of the cancer and your health.

    For early stage lung cancer, surgery may be successful at removing the entire tumor and cancer cells. In some cases, no other treatment is needed.

    In other cases, along with surgery, you may need treatments like chemotherapy, immunotherapy, targeted therapies, radiation, or a combination to eliminate any remaining cancer cells.

    You may also receive other treatments, such as medication for pain, infection, or nausea, to help reduce any uncomfortable symptoms or side effects of treatment.

    Treatment for late stage NSCLC

    Chemo and other treatments, such as immunotherapy and targeted therapies, can help slow or stop the growth of cancer cells if the cancer has spread or you're not healthy enough for surgery.

    In most cases, the goal of treatment is to help relieve symptoms and prolong life rather than to cure the cancer.

    Radiation is another option for treating tumors that cannot be removed surgically. It involves targeting tumors with high energy radiation to shrink or eliminate them.

    Treatment for symptoms

    In addition to treatments designed to slow, halt, or eliminate cancer cells, you may need additional care to help relieve your symptoms.

    Tumors can cause pain, and even if they can't be eliminated completely, their growth can be slowed with chemotherapy, radiation, or lasers. A doctor can create a treatment plan to help ease any pain you have.

    Tumors in the airways of the lungs can cause difficulty breathing. Laser therapy, or a treatment called photodynamic therapy, can shrink tumors that are blocking your airways. This can help restore normal breathing.

    What is the life expectancy with non-small cell lung cancer?

    A person's life expectancy with non-small cell lung cancer depends on the cancer stage, subtype, specific tumor mutations, and other factors such as age and overall health.

    The 5-year average survival rate ranges from 9–65%, depending on the extent of disease.

    How treatable is non-small cell lung cancer?

    Doctors can treat NSCLC with surgery, chemotherapy, radiation, immunotherapy, and targeted therapies. The success of treatments can depend on the cancer stage and tumor genetics, as well as other factors.

    What is the most aggressive lung cancer?

    Small cell lung cancer (SCLC) is more aggressive than non-small cell lung cancer (NSCLC).

    Living with any kind of cancer isn't easy. Along with physical symptoms, you may also experience emotional distress, anxiety, or fear.

    To cope with these feelings, make sure that you're honest and open with your medical team. You may be referred to a psychologist or counselor to help you cope with mental and emotional challenges.

    It can help to reach out to close family or friends to help support you during this difficult time. Your loved ones can help assist you and listen to your concerns.

    It can also be powerful to connect with other people who are living with NSCLC.

    Speak with a member of your care team about finding a support group for those who have been diagnosed with or who have survived cancer. Online support groups are another option.

    Cancer can be considered a chronic condition. Even when tumors are eliminated, there is no guarantee that they won't come back. Recurrence is possible with any type of cancer.

    You will likely receive regular testing for recurrences and receive additional treatment should one occur.


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    Lung Cancer Symptoms: What You Should Know

    Most of the time, lung cancer has no symptoms in its early stages. Your lungs don't have many nerve endings, so a tumor can start to grow there without causing pain. You may not notice the signs until your cancer has begun to spread.

    When signs of the disease start to appear, they can include:

  • Chronic, hacking, raspy coughing, sometimes with mucus that has blood in it
  • Changes in a cough that you've had for a long time
  • Respiratory infections that keep coming back, including bronchitis or pneumonia
  • Shortness of breath that gets worse
  • Wheezing
  • Lasting chest pain
  • Hoarseness
  • Trouble swallowing
  • Shoulder pain
  • These problems usually happen because of blocked breathing passages or because the cancer has spread farther into the lung, nearby areas, or other parts of the body.

    Early-stage lung cancer often has few symptoms. When it's caught early, it's usually because the patient had a screening. (Photo Credit: E+/Getty Images)

    Stage I lung cancer symptoms

    This early stage of lung cancer often doesn't cause any symptoms. Stage I lung cancer is more likely to be caught because you had a screening, not because you noticed anything wrong. If you do have symptoms, they may include:

  • Coughing, especially a new cough, one that has become constant, or one that's bringing up blood or mucus 
  • Shortness of breath
  • Chest pain
  • Frequent infections such as bronchitis or pneumonia
  • Stage IV lung cancer symptoms

    When your cancer reaches this stage, it has begun to spread to more spots in your lungs, the fluid around your lungs, or other places in your body. In addition to respiratory symptoms such as coughing and wheezing, you may have:

  • Fatigue
  • Weakness
  • Loss of appetite
  • Weight loss
  • Headaches, numbness, or seizures if it has spread to your brain
  • Less common lung cancer symptoms

    Some symptoms affect parts of your body that don't seem related to to your lungs. Those signs include:

  • Changes to your fingers, known as "clubbing." Your nails curve more than usual, and your skin and nails look shiny. The ends of your fingers appear bigger.
  • Too much calcium in your blood (hypercalcemia), which can cause stomach upset, thirst, frequent urination, and confusion among other symptoms.
  • Horner syndrome, which can cause a drooping eyelid, decreased pupil size, and reduced sweating -- all on one side of your face.
  • Puffy face, neck, or arms, caused by a tumor restricting blood flow.
  • Lung cancer symptoms on the skin

    In addition to sweating issues caused by Horner syndrome, lung cancer can cause other issues with your skin. They include:

  • Jaundice, which causes your skin and the whites of your eyes to turn yellow
  • Bruising easily, which happens when the cancer interferes with your body's adrenal glands
  • Lung cancer is the leading cause of cancer deaths among all genders. Lung cancer rates are falling across the board, but the decline hasn't been as big for younger women. Experts aren't sure why this is happening. Genetic mutations may play a role. Lung cancer has traditionally been associated with older men who have a history of smoking, so doctors may not suspect lung cancer at first when a nonsmoking young woman comes in with general symptoms such as cough or frequent respiratory infections.

    There are two main types of lung cancer: small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). NSCLC is more common and makes up about 85% of all lung cancer cases. Within NSCLC, there are three subtypes:

  • Adenocarcinoma, which often forms in the outer layers of your lungs. More women get this type, and experts are seeing more of it among women who have never smoked.
  • Squamous cell carcinoma, which usually forms in the center of your lung, next to an air tube (bronchus).
  • Large cell carcinoma, which can form anywhere and usually grows faster than the other two types.
  • There are two types of SCLC, mainly based on the type of cells involved and how they look under a microscope: small-cell carcinoma and mixed small-cell/large-cell cancer. It's sometimes called combined small-cell lung cancer. SCLC is strongly linked to cigarette smoking.

    Both SCLC and NSCLC have many symptoms in common: cough, chest pain, wheezing, and hoarseness, for instance.

    Non-small-cell lung cancer symptoms

    NSCLC is more likely than SCLC to cause Horner syndrome, the collection of symptoms that affects your pupil, eyelid, and sweating on one side of your face.

     Small-cell lung cancer symptoms

    This type tends to grow and spread more quickly to other parts of your body. That means it's more likely to produce symptoms, such as:

  • Bone pain
  • Confusion
  • Seizures
  • Paralysis
  • SCLC is more likely than NSCLC to cause hypercalcemia and interfere with your adrenal glands.

    If you have any of these symptoms of lung disease, especially an ongoing cough, blood-streaked mucus, wheezing, hoarseness, or a lung infection that keeps coming back, see your doctor. You'll get a thorough checkup, and you may also get X-rays or other tests.

    Go immediately to the emergency room if you have any of the following:

    In its early stages, lung cancer often has no symptoms. If you're coughing up mucus (especially if it's streaked with blood), have wheezing, hoarseness, chest pain, or frequent cases of bronchitis or pneumonia, these can be signs of lung cancer. Many of the symptoms of SCLS and NSCLC are the same. Those symptoms can also be signs of other illnesses. It's important to talk to your doctor if you have concerns.

    How long can you have lung cancer without knowing?

    Lung cancer can grow in your body for years before you start to notice symptoms.

    Is cancer in the lungs curable?

    Experts generally don't use the word "cured" when it comes to lung cancer. They're more likely to say you're in "remission" or that your body shows "no evidence of disease" (NED). At 5 years or more of remission or NED, your doctor might consider you cured. The earlier your cancer is found and you begin treatment, the better your outcome is likely to be. That's why experts have begun to encourage lung cancer screening for certain people at higher risk. You may want to look into the benefits of screening if you meet these requirements:

  • You're between the ages of 50 and 80
  • You smoke, or you quit within the last 15 years
  • You have a smoking history of 20 pack years. That's the number of packs per day multiplied by the number of years you smoked.
  • How long can you live with lung cancer?

    How long you'll live depends on many factors, including:

  • What type of cancer you have
  • How far it's spread
  • How well you respond to treatment
  • Your overall health
  • The survival rates for lung cancer have been increasing with the development of new treatments.






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